Dr Ali Fouladi-Nashta
DVM, MSc, PhD, FHEA
Reader in Reproductive Biology and Technology
Department: Comparative Biomedical Sciences
Campus: Hawkshead
Research Groups: Sustainable Food Systems, IRLFS (Research Programme), CPCS (Research Programme)
Ali is a member of the Reproduction Research Group. His research is based on oocyte biology and embryology of domesticated and farm animal species and uterine embryo interaction and mechanism of embryo implantation.
Ali trained as a Veterinarian in Tehran University and served for about 7 years as a Lecturer in Animal Reproduction before moving to the United Kingdom for further education. He gained his MSc in 1995 and PhD in 1999 from the University of Edinburgh in Scotland.
Ali undertook at PhD at the Roslin Institute where he worked alongside Professor Keith Campbell, creator of Dolly the cloned sheep from differentiated cells. Following this he moved on to undertake post-doctoral work at the University of Manchester, investigating the role of Leukaemia Inhibitory Factor with Sue Kimber. Subsequently he joined Nottingham University as a Research Fellow working with Professor Bob Webb to investigate the effects of diet on oocyte & embryo quality in lactating dairy cows.
In June 2006, Ali accepted a Lectureship position at the °ÄÃÅÁùºÏ²Ê¹æÂÉÂÛ̳ (Department of Veterinary Basic Sciences). His research in the area of female reproduction continues. He was promoted to Senior Lecturer position in 2012 and then to Reader position in September 2016.
During his time at the Roslin Institute Ali's studies established that improvement in cytoplasmic maturation of bovine oocytes improves the rate of blastocyst development (Fouladi-Nashta et al., 1998, Biology of Reproduction 59: 255-262).
At the University of Manchester Ali investigated the role of leukaemia inhibitory factor (LIF) on implantation of embryos in mice. Using LIF gene knocked-out mice he showed misregulation of signalling mechanisms and absence of changes in the uterine endometrium associated uterine receptivity (Fouladi-Nashta et al., 2005, Developmental Biology, 281:1-21) resulting in infertility. They also demonstrated that LIF inhibitor can effectively inhibit its effects on decidualisation of uterine stroma cells (Fouladi-Nashta et al., 2004, Journal of Endocrinology, 181: 477-492).
Whilst at Nottingham University Ali investigated the effects of diet on oocyte and embryo quality in lactating dairy cows. Diets can modify the profiles of hormones and local production of growth factors thereby influencing reproductive function (Fouladi-Nashta et al., 2007, Biology of Reproduction 77: 9-17). He developed diets which can promote reproductive cyclicity and also increase pregnancy rate in post-calving dairy cows (Garnsworthy et al., 2008). He also developed a simple and fast but reliable technique for assessment of blastocysts (Reproductive BioMedicine Online, 2005, 10: 497-502).
Gerri, C; Mccarthy, A; Alanis-Lobato, G; Demtschenko, A; Bruneau, A; Loubersac, S; Fogarty, N M E; Hampshire, D; Elder, K; Snell, P; Christie, L; David, L; Van de Velde, H; Fouladi-Nashta, A; Niaken, K K
Nature, 587 (7834), 443-447. 2020.
Marei, W F A; Khalil, W A; Pushpakumara, A P G; El-Harairy, M A; Abo El-Atta A M A; Wathes, D C; Fouladi-Nashta, A A.
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International Journal of Veterinary Science and Medicine, 2018
Hanousek K, Salavati M, Fouladi-Nashta A. (2018) Vet Rec. 2018 Mar 23. pii: vetrec-2017-104719. doi: 10.1136/vr.104719
Tremaine TD, Fouladi-Nashta AA. (2018) Immunolocalization Reprod Domest Anim. 2018 Mar 5. doi: 10.1111/rda.13156.
Soto-Heras S, Roura M, Catalá MG, Menéndez-Blanco I, Izquierdo D, Fouladi-Nashta AA, Paramio MT. (2018) Differential J Dairy Sci. 100:9324-9337.
Husna AU, Azam A, Qadeer S, Awan MA, Nasreen S, Shahzad Q, Fouladi-Nashta A, Khalid M, Akhter S. (2017) Reprod Domest Anim. 2018 Apr;53(2):377-384. doi: 10.1111/rda.13117. Epub 2017 Dec 14.
Goodarzi A, Zare Shahneh A, Kohram H, Sadeghi M, Moazenizadeh MH, Fouladi-Nashta A, Dadashpour Davachi N. Theriogenology. 2018 Jan 15;106:265-270. doi: 10.1016/j.theriogenology.2017.10.009.
Zhang SD, Dong SW, Wang DS, Oguejiofor CF, Fouladi-Nashta AA, Yang ZQ, Yan ZT. (2017) J Dairy Sci. 2017 Nov;100(11):9324-9337. doi: 10.3168/jds.2016-12365. Epub 2017 Sep 13.
Roura M, Catalá MG, Soto-Heras S, Hammami S, Izquierdo D, Fouladi-Nashta A, Paramio MT. (2017) Reprod Fertil Dev. doi: 10.1071/RD17174. [Epub ahead of print]
Soto-Heras S, Roura M, Catalá MG, Menéndez-Blanco I, Izquierdo D, Fouladi-Nashta AA, Paramio MT (2017) Reprod Fertil Dev. 2017 Jun 19. doi: 10.1071/RD17170. [Epub ahead of print]
Fouladi-Nashta AA, Raheem KA, Marei WF, Ghafari F, Hartshorne GM (2016). Regulation and roles of hyaluronan system in mammalian reproduction. Reproduction 153 (2):R43-R58.
Marei WFA, Wathes DC, Raheem KA, Mohey-Elsaeed O, Ghafari F, Fouladi-Nashta AA (2016). Reprod Fertil Dev. 2017 Sep;29(9):1763-1773. doi: 10.1071/RD16232.
Marei WF, Tremaine T, Salavati M, Khalid, M and Fouladi-Nashta AA. (2016) Theriogenology. 2016 Sep 1;86(4):940-948.
Raheem KA, Marei WFA, Campbell BK, Fouladi-Nashta AA. (2016) Theriogenology 85:1635-1643.
Yousefi AR, Kohram H, Zare Shahneh A, Zamiri MJ, Fouladi-Nashta AA. (2016) Theriogenology. 2016 Jan 19. doi:10.1016/j.theriogenology.2016.01.015.
Oguejiofor CF, Cheng Z, Abudureyimu A, Fouladi-Nashta AA, Wathes DC. (2015) Biol Reprod. 93(4):100. doi: 10.1095/biolreprod.115.128868. Epub 2015 Sep 9.
Oguejiofor CF, Cheng Z, Abudureyimu A, Anstaett OL, Brownlie J, Fouladi-Nashta AA, Wathes DC. (2015) Biol Reprod. 93(4):101. doi: 10.1095/biolreprod.115.128876. Epub 2015 Sep 9.
Mohey-Elsaeed O, Marei WF, Fouladi-Nashta AA, El-Saba AA. (2015) Reprod Fertil Dev. doi: 10.1071/RD14187. [Epub ahead of print]
Chavoshinejad R, Marei WF, Hartshorne GM, Fouladi-Nashta AA. (2014) Reprod Fertil Dev. doi: 10.1071/RD14294. [Epub ahead of print]
Ghaffarilaleh V, Fouladi-Nashta A, Paramio MT. (2014) Theriogenology. 82:686-96.
Marei WF, Abayasekara DR, Wathes DC, Fouladi-Nashta AA.( 2014) Reprod Biomed Online. 28:388-400.
Raheem KA and Fouladi-Nashta AA. (2014) Isolation and characterization of endometrial luminal epithelial and stromal cells in vitro. Sokoto J Vet Sci, 12:1-8.
Salavati M, Ghafari F, Zhang T, Fouladi-Nashta AA. (2013) Theriogenology 80:784-92.
Wathes DC, Cheng Z, Marei WF, and Fouladi-Nashta AA (2013) Polyunsaturated fatty acids and fertility in female mammals: an update. CAB reviews 2013 8, N0. 041. doi: 10.1079/PAVSNNR20138041
Raheem KA, Marei WF, Mifsud K, Khalid M, Wathes DC, Fouladi-Nashta AA. (2013) Reproduction. 145:491-504.
Marei WF, Salavati M, Fouladi-Nashta AA (2013) Mol Hum Reprod. 19:590-9.
Swangchan-Uthai T, Chen Q, Kirton SE, Fenwick MA, Cheng Z, Patton J, Fouladi-Nashta AA, Wathes DC. (2013) Reproduction 145:527-39.
Swangchan-Uthai T., Lavender C.R., Cheng Z., Fouladi-Nashta A.A., Wathes D.C. (2012) Biol Reprod. 87:135, 1–13
Dirandeh E, Towhidi A, Zeinoaldini S, Ganjkhanlou M, Ansari Pirsaraei Z, Fouladi-Nashta A. (2013) J Anim Sci. 91:713-21.
Salavati M., Ghafari F., Zhang T., Fouladi-Nashta A.A. (2012) Effects of oxygen concentration on in vitro maturation of canine oocytes in a chemically defined serum free media. Reproduction 144: 547-56.
Marei W.F., Ghafari F., Fouladi-Nashta A.A. (2012) Role of hyaluronic acid in maturation and further early embryo development of bovine oocytes. Theriogenology 78: 670-7.
Marei W.F., Wathes D.C., Fouladi-Nashta A.A. (2012) Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes, Reproduction Fertility and Development 24: 679-90.
Marei WF, Wathes DC, Fouladi-Nashta AA (2011) Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. Reproduction Fertility and Development 24: 679–690.
Marei W.F., Wathes D.C., Fouladi-Nashta A.A. (2010) Impact of linoleic acid on bovine oocyte maturation and embryo development. Reproduction 139: 979-988.
MAREI, W.F., WATHES, D.C. & FOULADI-NASHT, A.A. (2009) The effect of linolenic Acid on bovine oocyte maturation and development. Reproduction. 138: 771-81.
FOULADI-NASHTA, A.A.,WONNACOTT, K.E., GUTIERREZ, C.G, GONG, J.G., SINCLAIR, K.D., GARNSWORTH, P.C. & WEBB, R. (2009) Oocyte quality in lactating dairy cows fed on high levels of n-3 and n-6 fatty acids. Reproduction 138, 771-81.
GARNSWORTH, P.C., FOULADI-NASHT, A.A., MANN, GE., SINCLAIR, K.D. & WEBB, R. (2009) Effect of dietary-induced changes in plasma insulin concentrations during the early post partum period on pregnancy rate in dairy cows. Reproduction.
FOULADI-NASHTA, A. A., MOHAMET, L., HEATH, J. K. & KIMBER, S. J. (2008) Interleukin 1 signaling is regulated by leukemia inhibitory factor (LIF) and is aberrant in Lif-/- mouse uterus. Biol Reprod 79, 142-153.
FOULADI-NASHTA, A. A., GUTIERREZ, C. G., GONG, J. G., GARNSWORTHY, P. C. & WEBB, R. (2007) Impact of dietary fatty acids on oocyte quality and development in lactating dairy cows. Biol Reprod 77, 9-17.
SINGH, R., FOULADI-NASHTA, A. A., LI, D., HALLIDAY, N., BARRETT, D. A. & SINCLAIR, K. D. (2006) Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation. J Cell Biochem 99, 146-155.
FOULADI-NASHTA, A. A. & CAMPBELL, K. H. (2006) Dissociation of oocyte nuclear and cytoplasmic maturation by the addition of insulin in cultured bovine antral follicles. Reproduction 131, 449-460.
NICHOLAS, B., ALBERIO, R., FOULADI-NASHTA, A. A. & WEBB, R. (2005) Relationship between low-molecular-weight insulin-like growth factor-binding proteins, caspase-3 activity, and oocyte quality. Biol Reprod 72, 796-804.
FOULADI-NASHTA, A. A., JONES, C. J., NIJJAR, N., MOHAMET, L., SMITH, A., CHAMBERS, I. & KIMBER, S. J. (2005) Characterization of the uterine phenotype during the peri-implantation period for LIF-null, MF1 strain mice. Dev Biol 281, 1-21.
FOULADI-NASHTA, A. A., ALBERIO, R., KAFI, M., NICHOLAS, B., CAMPBELL, K. H. & WEBB, R. (2005) Differential staining combined with TUNEL labelling to detect apoptosis in preimplantation bovine embryos. Reprod Biomed Online 10, 497-502.
FOULADI NASHTA, A. A., ANDREU, C. V., NIJJAR, N., HEATH, J. K. & KIMBER, S. J. (2004) Role of leukemia inhibitor factor (LIF) in decidualisation of murine uterine stromal cells in vitro. J Endocrinol 181, 477-492.